Paper Title:
Biological Safety Assessment of a Colored Zirconia Ceramic: Cell Toxicity and Skin Sensitivity Tests
  Abstract

Objective: To evaluate the biological safety of a colored zirconia ceramic in terms of cellular toxicity and a skin sensitivity test. Methods: the cytotoxicity of the ceramic was evaluated by a molecular filtration method and skin irritation activity of the composite was assessed via intradermal injection of a guinea pig test solution, by inducing, enhancing, and stimulating an allergic response after local tissue exposure. Results: cell-coated filter paper in contact with test material showed the appearance of intracellular blue dye at the same staining density as in control samples, leading to a 0 toxicity rating. Guinea pigs showed no obvious erythema or edema from the irritation test, such that the assessment of colored zirconia ceramic skin allergy response in guinea pig was 0%. Conclusion: this colored zirconia ceramic showed low cytotoxicity and elicited no allergic skin inflammation response, indicating good overall biological safety under these conditions.

  Info
Periodical
Edited by
Yiwang Bao, Danyu Jiang, Li Tian and Jianghong Gong
Pages
509-512
DOI
10.4028/www.scientific.net/KEM.492.509
Citation
H. X. Lu, B. Deng, L. Q. Shao, Y. F. Yi, J. Liu, W. W. Zhang, N. Wen, "Biological Safety Assessment of a Colored Zirconia Ceramic: Cell Toxicity and Skin Sensitivity Tests", Key Engineering Materials, Vol. 492, pp. 509-512, 2012
Online since
September 2011
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Price
$32.00
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