Paper Title:
Nanostructured Bone Grafting Substitutes – A Pathway to Osteoinductivity
  Abstract

The comparative investigation of a highly nanoporous bone grafting material (NanoBone S, NBS) and a sintered hydroxyapatite ceramic (Cerabone, CB) aimed to show the influence of the structure of the material on osteoinductivity.NBS consists of synthetic nanocrystalline hydroxyapatite embedded in a porous silica gel matrix. Its specific surface amounts 206 m2/g in contrast to CB with a specific surface of 0.4 m2/g.The biomaterials were implanted in the neck region of 18 sheep and left there for the periods of 6, 12 and 26 weeks. In each case granulate was implanted superficially into the trapezius muscle and into the subcutaneous adipose tissue respectively. The samples were analysed by micro-CT, histochemistry, immunohistochemistry and histomorphometry. In the case of NBS ossicles had developed. An intensive remodelling process was verifiable. The bone formation in CB was marginal.As a basic phenomenon in NBS, the substitution of the original SiO2 gel matrix by organic molecules forming an organic matrix around the embedded hydroxyapatite seams to be the key event causing these results.

  Info
Periodical
Key Engineering Materials (Volumes 493-494)
Main Theme
Edited by
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
Pages
147-152
DOI
10.4028/www.scientific.net/KEM.493-494.147
Citation
T. Gerber, S. Lenz, G. Holzhüter, W. Götz, K. Helms, C. Harms, T. Mittlmeier, "Nanostructured Bone Grafting Substitutes – A Pathway to Osteoinductivity", Key Engineering Materials, Vols. 493-494, pp. 147-152, 2012
Online since
October 2011
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