Paper Title:
Antibiotic Delivery Effects from HA on Bone Cement in the Interface Bioactive Bone Cement for Prevention of Infection in Joint Replacement
  Abstract

Antibiotics release impregnated in HA granules, which were used in IBBC to prevent infection after total joint arthroplasty, was measured. For antibiotics, Flumarin, Vancomycin, Pansporin and Firstcin were used. Two models of antibiotics release were assumed; Model [I]: antibiotics release from surroundings of HA granules immediately after surgery and Model [II]: antibiotics release loaded on HA after antibiotics release from surroundings of HA granules as follows; (1) loading in normal pressure and (2) loading in reduced pressure. The amount of antibiotics loaded on HA is higher when loading is conducted under reduced pressure than that under normal pressure. Firstcin showed the highest loaded amount and the most desirable sustained release pattern. The antibiotics release from HA are varid depending on the antibiotics used.

  Info
Periodical
Key Engineering Materials (Volumes 493-494)
Main Theme
Edited by
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
Pages
361-365
DOI
10.4028/www.scientific.net/KEM.493-494.361
Citation
H. Oonishi Jr., T. Arita, A. Tachibana, T. Tanabe, S. Mizokawa, H. Oonishi, "Antibiotic Delivery Effects from HA on Bone Cement in the Interface Bioactive Bone Cement for Prevention of Infection in Joint Replacement", Key Engineering Materials, Vols. 493-494, pp. 361-365, 2012
Online since
October 2011
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Price
$32.00
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