The occlusal design of dental restorations should stay in harmonic relation to the remaining dentition. In CAD/CAM dentistry, the occlusion is generated by the CAD software based on standard morphologies from the dental database. An automated adaptation process of this standard morphology to an individual clinical situation is difficult and leading to manual adaptation of the proposal with design tools. The new biogeneric software of the chairside CAD/CAD system (CEREC) automatically collects optic measurement of the preparation side including mesial and distal neighbor teeth and antagonist teeth to design a restoration with a patient specific occlusal morphology. This clinical report demonstrated a case, which was treated with ceramic onlay designed and milled with CEREC system used in biogeneric design mode. Digital impression of the preparation was taken with the intraoral camera. Buccal scan,technique was used for taking the occlusal record. Preparation and antagonist images were automatically correlated by software and a virtual articulator was created. After trimming the virtual model, preparation margins were outlined with the automatic margin finder option of the software and then the insertion axis of the restoration was determined. The biogeneric restoration proposal was then automatically seated to the virtual model and desired changes were performed with the design tools of the software. The restoration was milled from feldspathic ceramic block.