The single anterior tooth replacement remains a complex aesthetic challenge for clinicians and technicians in prosthetic dentistry. Maxillary central incisors are the key point of an esthetic smile and should exhibit a high degree of symmetry across the midline. Matching the shape and contours to the adjacent central incisor is the crucial factor to achieve an esthetic result. The CEREC system is the first to use chairside CAD/CAM system, which allows the dentist to provide ceramic restorations in a single appointment without time consuming laboratory procedures.This clinical report demonstrates the effective usage of CEREC system with the biogeneric reference design mode for designing and milling of a laminate veneer restoration in one appointment.Digital images of the preparation and bite registration were captured using an intraoral camera and virtual models were created. With the biogeneric reference design mode of CEREC 3.0 software, the image of the contralateral central incisor is mirrored, positioned over the preparation, and then refined. Among a variety of ceramic blocs available for CEREC system, the restoration was milled from feldspathic ceramic block.