Paper Title:
The Effect of Si(IV) Species Derived from Chitosan-Silicate Hydrogels on Osteoblast Behavior
  Abstract

Chitosan-GPTMS (γ-Glycidoxypropyltrimethoxysilane) hybrid hydrogels were synthesized with β-glycerophosphate (β-GP) as the additive agent. Chitosan-GPTMS sols were fluid at room temperature and transformed to hydrogel at 36.5°C in several min. The gelation time of the hydrogels was shortened by the addition of GPTMS. From NMR experiments, this gelation behavior depended on some factors, namely, electrostatic interaction between the phosphate groups of β-GP and the amino groups of chitosan chains, crosslinking between the epoxy groups of GPTMS and the amino groups of chitosan, and polycondensation of the methoxy groups of GPTMS. The Si(IV) released from the hydrogels promoted the cell adhesion and ALP activity of osteoblastic cells MG63.

  Info
Periodical
Key Engineering Materials (Volumes 493-494)
Main Theme
Edited by
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
Pages
698-702
DOI
10.4028/www.scientific.net/KEM.493-494.698
Citation
Y. Shirosaki, S. Hayakawa, A. Osaka, "The Effect of Si(IV) Species Derived from Chitosan-Silicate Hydrogels on Osteoblast Behavior", Key Engineering Materials, Vols. 493-494, pp. 698-702, 2012
Online since
October 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Kanji Tsuru, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, M.A. Lopes, José D. Santos, Maria Helena F.V. Fernandes
Abstract:Chitosan-silicate hybrid membranes were prepared using g-glycidoxy-propyltrimethoxysilane (GPSM) through a sol-gel process. The amino groups...
823
Authors: Ricardo M.P. da Silva, João F. Mano, Rui L. Reis
Abstract:Fosfosal, a phosphate derivative of salicylic acid, which presents both analgesic and antiinflammatory properties, was used as a model drug...
990
Authors: Hyun Jung Lee, Keun Hong Park, So Ra Park, Byoung Hyun Min
Abstract:Acknowledging the supportive influence of matrix molecules on the chondrocytic phenotype, we combined heparin and chitosan to develop a...
329
Authors: Nan Xing, Feng Tian, Jian Yang, Yu Kun Li
Chapter 3: Material Engineering and Science
Abstract:The aim of this study is to evaluate the characterizations of alginate-chitosan hydrogel for wound dressing application. The influence of...
3124
Authors: Song Chen, Nobutaka Hanagata
Chapter 1: Advanced Bio-, Medical-Material Technology and Application
Abstract:Silica-chitosan hybrid was synthesized from a mixture of chitosan and glycidyloxypropyltrimethoxysilane and then coated on a microgrooved...
165