This paper selected wetland area in Ganjiahu as research area which impacts of human activity was evident and analyzed the soil enzyme activity of each five edge land-use types (reed wetland, salt meadow, Populus euphratica, Haloxylon ammodendro, farm land), results showed that: Under the effects of different land use types, the impact of the enzyme activity causes its surface layer soil to the catalase to be higher, and in the vertical direction, the soil enzyme activity assumes declining trend along with the depth change. It`s the biggest changing scope among each layer of the enzyme activity in the Populus euphratica. Secondly, each layer of the farmland and reed wetland enzyme activity has the sub-change scope. The average value of enzyme activity of urease exists a declining tendency from the soil surface to the bottom, in which the changing scope of the enzyme activity of each layer in the salt meadow is the biggest. Correespondingly, the each layer of farm land, Populus euphratica and reed wetland enzyme activity has the sub-change scope. The enzyme activity of sucrase exists a declining tendency from the soil surface to the bottom,Each changing scope of the soil enzyme activity in the Populus euphratica is the biggest, the salt meadow and reed wetland`s soil enzyme activity is relatively smaller, and each changing scope of sucrase activity in farm land is not obvious. soil is not obvious to the proteinase activity influence, which indicating that the proteinase is unable representative to reflect this area soil fertility condition . whereas four kinds of enzyme activities in the Haloxylon ammodendro are relatively low, and each change is not obvious, instructing that the disturbance by human are more lightly. Soil enzymes as part of the soil, it plays an important role in the transformation of nutrients, organic matter decomposition, degradation and restoration of pollutants .Soil enzyme is kind of substances which remains catalytic ability of decomposition in the soil, it is from microorganisms, plants, animals and there living secretion of debris . In recent years, scholars have paid a lot of attention in the soil enzyme activities as indicators of soil quality research in biological activity , they think that the land use could affected significantly enzyme activity of soil, determination of soil enzyme activity and quality has become indispensable. But on the research of soil enzyme activities in the wetland soil of arid desert edge is lack. This paper study the soil enzyme in different land use in Xinjiang Ganjiahu Wetland edge, and discuss the human activities on wetland and ecosystem interference mechanism, in order to carry out construction projects of wetland degradation and restoration and provide evidence.