Synthesis and Characterization of Epothilone B Molecular Imprinted Polymers
| Periodical | Key Engineering Materials (Volume 501) |
|---|---|
| Main Theme | Progress in Polymer Processing |
| Edited by | Chi Zhang |
| Pages | 37-41 |
| DOI | 10.4028/www.scientific.net/KEM.501.37 |
| Citation | Guo Li Gong et al., 2012, Key Engineering Materials, 501, 37 |
| Online since | January, 2012 |
| Authors | Guo Li Gong, Lin Jia, Hui Li |
| Keywords | Epothilone B, Molecular Imprinted Polymer (MIP), Molecularly Imprinted |
| Price | US$ 28,- |
Molecular imprinted polymers (MIPs) for antitumor drug Epothilone B have been synthesized with bulk polumerization in order to specifically extract this agent in the present study. MIP was prepared by thermal polymerisation using Epothilone B as template, methacrylic acid as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linking agent. The best synthesis progenic solvent was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Epothilone B was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 3.37 mg/ml, the maximum apparent adsorption was 335 mg/g.
