A new high strength titanium alloy system with low cost alloying elements, such as Al, Fe, has been recently developed. In present study the expensive V was replaced with Fe, and Si was added from 0 to 7.5wt.%. The effect of Fe and Si on the microstructure and tensile properties of Ti-6Al-4Fe-xSi (x=0, 0.1, 0.25, 0.5, 0.75wt.%) alloys was investigated. The room and high temperature mechanical properties of Ti-6Al-4Fe alloys were better than those of the Ti-6Al-4V. It was mainly due to the phase boundary strengthening at ambient and high temperature. The strength and elongation of the developed alloys depended upon the Si contents. The Si elements made the grain boundary and colony size fine, and increased the strength of the developed alloys by solid solution and precipitation hardening. The tensile strength variation with the Si contents at room temperature and 400°C, and at 450°C and 500°C showed a similar behavior, respectively.