A series of experiments were carried out on normal and high speed milling of a high strength titanium alloy (TA15). TA15 is a close alpha titanium alloy strengthened by solid solution with Al and other component. It is often used to make large structural parts in airplane and welded parts subject to heavy load. The tool life of several typical types of cutter commonly used in the milling of titanium alloy was studied by the orthogonal experiment design method. After multi-element regression analysis, the empirical equation of the tool life was stablished. The milling force and temperature were measured under different cutting conditions and tool wear status. The knowledge is useful to further understand and analysis of the cutting mechanism, machining quality and tool wear. The study on the machined surface integrity includes the following content: surface roughness, metallographic examination, work hardening and residual stress.