TbDyFe is a rare earth-iron magnetostrictive alloy with “giant” magnetostrain, good magnetomechanical coupling factor and fast response. Giant magnetostrictive actuators (GMAs) are designed and fabricated with home-made TbDyFe rods. Their magnetostrain properties under varied operation are tested. The static output displacement up to 100μm and output force up to 1500N were obtained. The dynamic displacement increases with amplitude under fixed frequency and decreases with frequency under fixed amplitude generally. The maximum dynamic output displacement of 146µm was obtained at natural frequency around 5Hz. Active vibration control employing GMA was implemented in the flexible structure. The excellent damping effect, 20-30 dB under the frequency range from 10Hz to 100Hz was obtained. The dynamic phase delay of GMA has been analyzed. A novel improved FSLMS algorithm is proposed to achieve a better control performance.