Paper Title:
Materials Selection and Scaffold Construction for Liver Tissue Engineering
  Abstract

To design the scaffold with suitable properties for the development of tissue engineered livers, materials design, selection and scaffold construct are three dispensable steps to be followed consequently. Firstly, some natural materials such as collagen, chitosan and alignate as well as some prevailing aliphatic polyester such as poly(lactic acid) (PLA), polyglycolide (PGA) and their copolymers poly(lactide-co-glycolide) (PLGA) are selected and characterized by hepatocyte culture. The experimental results reveal that the natural materials with excellent biocompatibility are not suitable as the scaffold alone because of the poor mechanical properties. At same time, aliphatic polyesters with good mechanical properties and biodegrade abilities are also proved inapplicable for hepatocytes for the lack of right cell recognition sites. Among our study scope, the hybrid materials such as collagen/chitosan or collagen/chitosan/heparin are the very promising candidates for hepatic tissue engineering scaffold. Secondly, two novel designs composed of collagen and PLGA, namely, the spindle porous scaffold with separated channels for transportation of nutrient, plasma and the one made by dewaxen-casting method are initiated respectively.

  Info
Periodical
Materials Science Forum (Volumes 475-479)
Main Theme
Edited by
Z.Y. Zhong, H. Saka, T.H. Kim, E.A. Holm, Y.F. Han and X.S. Xie
Pages
2391-2394
DOI
10.4028/www.scientific.net/MSF.475-479.2391
Citation
Q. L. Feng, "Materials Selection and Scaffold Construction for Liver Tissue Engineering", Materials Science Forum, Vols. 475-479, pp. 2391-2394, 2005
Online since
January 2005
Authors
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Hyun Jung Lee, Keun Hong Park, So Ra Park, Byoung Hyun Min
Abstract:Acknowledging the supportive influence of matrix molecules on the chondrocytic phenotype, we combined heparin and chitosan to develop a...
329
Authors: Anna Theocharidou, K. Tsoptsias, Eleana Kontonasaki, Lambrini Papadopoulou, C. Panayiotou, Konstantinos M. Paraskevopoulos, Petros Koidis
Abstract: Chitin is a polysaccharide abundant in nature. Its’ deacetylation product-chitosan- in combination with gelatin (collagen product) is...
866
Authors: Jayachandran Venkatesan, Se Kwon Kim
Chapter 4: Ceramic Materials / Superconducting Materials
Abstract:In the recent years, significant developments have been achieved with chitosan and hydroxyapatite (HAp) scaffolds for bone tissue...
212
Authors: Song Chen, Nobutaka Hanagata
Chapter 1: Advanced Bio-, Medical-Material Technology and Application
Abstract:Silica-chitosan hybrid was synthesized from a mixture of chitosan and glycidyloxypropyltrimethoxysilane and then coated on a microgrooved...
165
Authors: Aurora de Acutis, Carmelo de Maria, Giovanni Vozzi
Chapter 3: Wearable Body Sensors and Technology for Healthcare Applications
Abstract:The majority of strategies used in tissue engineering (TE) employ a scaffold, which is used to guide .the proliferation, the migration and...
151