Paper Title:
The Study of Apoptosis and Phagocytosis of Rabbit Synoviocytes Induced by Particulate Joint Replacement Materials
  Abstract

Synoviocyte is one of the cells in direct contact with the wear particles and the role of synoviocytes in the prosthesis loosening remains to be further understood. The purpose of the present study is to investigate whether particulate biomaterials cause synoviocyte dead or simply activate these cells. The activation of synoviocyte in response to particulate biomaterial exposure will be indicated with its phagocytotic ability. As to the effects of particulate biomaterials to apoptosis will be tested on rabbit synoviocytes, HIG-82 cells. The results demonstrate that the addition of cobalt particles would lead the HIG-82 cells to apoptosis and apoptosis accompanying caspase3 cleavage, which means that apoptosis of the HIG-82 cells resulted from the addition of cobalt particles might went through caspase-dependent pathway. On the other hand, exposing to nonmetal particles such as TiO2 and SiO2, particles did not provoke apoptosis of the HIG-82 cells. TiO2 particles activated the cells and were phagocytosed by the HIG-82 synoviocytes, no significant biological effects were found while the HIG-82 cells exposed to SiO2 particles.

  Info
Periodical
Materials Science Forum (Volumes 475-479)
Main Theme
Edited by
Z.Y. Zhong, H. Saka, T.H. Kim, E.A. Holm, Y.F. Han and X.S. Xie
Pages
2419-2422
DOI
10.4028/www.scientific.net/MSF.475-479.2419
Citation
C. T. Yung, S. S. Lian, Y.J. Sung, "The Study of Apoptosis and Phagocytosis of Rabbit Synoviocytes Induced by Particulate Joint Replacement Materials", Materials Science Forum, Vols. 475-479, pp. 2419-2422, 2005
Online since
January 2005
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Xiao Dan Qi, Jin Cai Hou, Hai Tao Yu, Chun Jing Zhang
Abstract:To study the underlying mechanism of 20 (S)-Ginsenoside-Rh2 and 20 (R)-Ginsenoside-Rh2 inducing apoptosis of human lung adenocarcinoma A549...
1205
Authors: Shu Li Shao, Wei Wei Zhang, Wei Zhao, Guang Hui Wu
Chapter 13: Structural Materials and Biomaterials
Abstract:To observe the effects of hydroxycamptothecine(HCPT) on the growth and apoptosis of gastric cancer cell line. The viability of human leukemia...
2420
Authors: Shu Li Shao, Bin Zhao, Wei Wei Zhang, Wei Zhao, Guang Hui Wu, Jin Ping Song
Chapter 1: Environmental Chemistry, Biology and Technology
Abstract:Objective: The research aimed to study the effects of mitomycin on human leukemic K562 cells, and to explore the mechanism of mitomycin...
71