The design of microstructure in materials, ranging from ultrafine, moderately sized, duplex to single crystalline, has long been a challenging subject to material scientists. A basic means to achieve this goal is related to the control of grain growth. Taking BaTiO3 as a model system, this investigation shows that control of grain boundary structure between rough and faceted and control of initial grain size can allow us to achieve the goal. When the grain boundary is rough, normal grain growth occurs with a moderate rate. On the other hand, for faceted boundaries, either abnormal grain growth or grain growth inhibition occurs resulting in a duplex grain structure or fine-grained structure, respectively. Growth of single crystals is also possible when the boundary is faceted. During crystal growth amorphous films can form and thicken at dry grain boundaries above the eutectic temperature. As the film thickness increases, the growth rate of the crystals is reduced. This observed growth behavior of grains with boundary structure is explained in terms of the difference in mobility between the two types of boundaries. The results demonstrate the basic principles of obtaining various microstructures from the same material.