Ti2AlNb orthorhombic phase based alloys are the promising high temperature structural materials for aeronautical and aerospace industry because of their low density, high yield strength and excellent high temperature performance. In this paper, the recent work which has been carried out in CISRI on alloy and process of Ti2AlNb based alloys is presented. The work covers the development of the alloy design and microstructure control as well as the processing technology applied for producing good quality alloy ingots and fabricating various components. The progress obtained in application research of the alloys is addressed. The important role that the combination of TMP and the post-TMP treatment affects on the microstructure and thus on the properties of the alloys is emphasized.