The characteristics of deformation of an orthorhombic phase based alloy, Ti-22Al-25Nb (at%), have been studied by hot compression tests in the temperature range of 940-1150°C with the strain rates of 0.01s-1 and 0.1s-1. A flow curves typically controlled by dynamic recovery were observed in the temperature range of 1090-1150 °C for the strain rate of 0.01s-1 , while discontinuous yield phenomena was found for the strain rate of 0.1s-1. The dynamic recovery can be identified by the microstructure characteristics of the deformation specimens. At 1060°C, the temperature of beta transus, the flow curves and microstructure exhibited the same deformation charateristics as that above the beta transus. At the subtransus temperature, a long period of flow softening followed by the steady-state flow can be observed. During the hot deformation, the hard phases α2 and O elongated, subboundary produced followed by cusp formation in the elongated α2 and O phases, the equiaxed morphology phases occurred by B2 phase penetrating along the subboundaries. The softening mechanism was discussed.