Paper Title:
Potential and Current Uses of Luminescence in Medical Diagnosis
  Abstract

Biological luminescence stimulated by optical excitation results in signals which are characteristic of the host tissue. The spectrum of the emitted light, the intensity, and the excited state lifetimes are modified as the result of disease or by activation through addition of cell selective phosphors. There is an opportunity to identify diseased tissue both by the spectral signals from activators or, in some cases, by the differences of the natural luminescence responses. For practical reasons, defined by the sensitivity range of standard luminescence detectors, much of the current work has focussed on the short wavelength emissions driven by laser activation. However, the techniques are poised to undergo a dramatic expansion in scope with the advent of higher sensitivity photocathodes with high efficiency responses at long wavelengths. It is now possible to utilise a greater range of emission features with improved discrimination. Further, movement to longer wavelength excitation, and emission, open the way to probe deeper beneath the surface of tissue. The current overview will focus on recent examples from detection of cancer to tooth caries and indicate how the non-destructive luminescence probes can distinguish between tissue changes at an early stage of development.

  Info
Periodical
Materials Science Forum (Volumes 480-481)
Edited by
A. Méndez-Vilas
Pages
411-416
DOI
10.4028/www.scientific.net/MSF.480-481.411
Citation
L. Avramaov, E. Borisova, P.D. Townsend, L.A. Valberg, "Potential and Current Uses of Luminescence in Medical Diagnosis", Materials Science Forum, Vols. 480-481, pp. 411-416, 2005
Online since
March 2005
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Feng Xu, Wei Liu, Xian Wei, Hong Li, De Jun Cao, Yi Lin Cao
Abstract:Tendon is an important supportive tissue of human body responsible for normal physical activity. However, tendon damage and defect remain an...
9
Authors: So Eun Lee, Young Mee Jung, Soo Hyun Kim, Sang Heon Kim, Jong Won Rhie, Young Ha Kim, Byoung Goo Min
Abstract:In cartilage tissue engineering, as a cell source, adult stem cells are very attractive for clinical applications. Recent studies suggest...
385
Authors: Lian Shun Zhang, Lei Fu, Kong Yang Zhao
Chapter 2: Material Science and Engineering
Abstract:Detection of interactions between light and biological material can be used to characterize the optical properties of the biological...
252
Authors: Sara Golbad, Mohammad Haghpanahi
Chapter 13: Materials and Design
Abstract:Pathologies in soft tissues are associated with changes in their elastic properties. Tumor tissues are usually stiffer than the fat tissues...
2116
Authors: Bing Hui Li, Yong Yu, Dan Xu
Chapter 1: Bio-, Chemical, Food Materials, Material Engineering and Technology
Abstract:The development of tissue engineering techniques for cartilage repair and regeneration provided a new way, according to their own...
68