Paper Title:
Quantum Dots CdSe/ZnS-Loaded Poly(D,L-Lactide-Co-Glycolide) Nanoparticles: Physicochemical Characterization and Application
  Abstract

This paper described and characterized the quantum dots (QDs) with/without the polymeric PLGA applied in MC3T3E-1 delivery. Neat QDs were treated with various solvents, temperatures, exposure time and concentration to evaluate their stability and efficacy. We found that the intensity degree of fluorescence spectra (QDs) in different solvents follows the order: ether > THF > acetone > chloroform > methanol. Importantly, the QDs become inactive after 8-hr dissolution in the solvents of ether, THF or chloroform. According to this result, acetone and methanol are ideal solvents for QDs. The optimum concentration range of QDs in acetone is 5 to 10 mg/mL. We found that no obvious difference of fluorescence intensity was detected in QDs stored respectively at 4 °C, 24 °C and 44 °C (8-hour). When QDs were exposed to UV light (312 nm) for 2 hr, serious decay of fluorescence intensity was observed. In order to extend the application of QDs in medical areas, we encapsulated them in individual biocompatible poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles for in-vitro imaging of endocytosis in MC3T3E-1 cells. We demonstrated that the polymeric PLGA have the ability to permeate the cells for cellular internalization; the endocytotic activity could be enhanced by the polymeric QDs-encapsulated PLGA.

  Info
Periodical
Materials Science Forum (Volumes 505-507)
Edited by
Wunyuh Jywe, Chieh-Li Chen, Kuang-Chao Fan, R.F. Fung, S.G. Hanson,Wen-Hsiang Hsieh, Chaug-Liang Hsu, You-Min Huang, Yunn-Lin Hwang, Gerd Jäger, Y.R. Jeng, Wenlung Li, Yunn-Shiuan Liao, Chien-Chang Lin, Zong-Ching Lin, Cheng-Kuo Sung and Ching-Huan Tzeng
Pages
667-672
DOI
10.4028/www.scientific.net/MSF.505-507.667
Citation
C. H. Yang, K. C. Lin, Y. H. Chang, Y. C. Lin, "Quantum Dots CdSe/ZnS-Loaded Poly(D,L-Lactide-Co-Glycolide) Nanoparticles: Physicochemical Characterization and Application", Materials Science Forum, Vols. 505-507, pp. 667-672, 2006
Online since
January 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Yi Wang, Hong Song Fan, Xian Tao Wen, Yu Mei Xiao, Zhong Wei Gu, Xing Dong Zhang
Abstract:Hydroxyapatite/polymer scaffolds with proper biomechanical properties and stable 3-D porous structure were fabricated by combining gas...
49
Authors: Xiu Lan Hu, Yoshitake Masuda, Tatsuki Ohji, Kazumi Kato
Abstract:Porous nano-scale ZnO particle film was rapidly synthesized from a mixing solution of zinc acetate dihydrate – acetone at about 90 °C. The...
123
Authors: Hong Yan Xu, Xing Qiao Chen, Ling Zhan Fang, Bing Qiang Cao
Chapter 9: Nano Materials
Abstract:In this paper, the precursors were synthesized by microwave hydrothermal method using SnCl4•5H2O and Ce(NO3)3·6H2O as raw material, CO(NH2)2...
1450
Authors: Li Guo, Yong Guo Zhang, Shi Zhao Yang
Chapter 4: Material Engineering and its Application Technology
Abstract:The influence of the solvent temperature and the solvent quality on the chain conformation and the aggregation of semiconducting block...
384
Authors: Peng Tian, Jing Zeng, Zhi Gang Zhao, Bo Meng, Tian Ling Qin, Lu Sun
Chapter 11: Materials and Processing Technologies
Abstract:1-methyl-3-butyl Imidazole chloride is prepared by 1–methyl imidazole and chlorinated n-butane. The synthesis reaction of 1-methyl-3-butyl...
2640