Paper Title:
Controlled Release of Active Substance from Biodegradable Copolymer Matrix
  Abstract

The purpose of this study is to develop a new system to control effective discharge of active substances such as agricultural chemicals. To synthesize a naturally dissolvable polymer; ε-caprolactone and diglycolide were copolymerized with ethylene glycol as an initiator to produce macrodiol. As macrodiol has hydroxyl groups in both ends, they are modified with methacryloyl chloride for photochemical networking. After standard macromonomer produced by this procedure was physically mixed with methylene blue, it was networked with ultra-violet rays to be filmed. This film is naturally dissolvable and hydrolytic. As a result of hydrolytic test with a crosslinked structure of 10 % methylene blue, it decreased by 9 % for seven weeks in 37 °C phosphate buffer solution (pH = 7). Thus, we verified that active substance can be discharged from a crosslinked structure for a long time at a constant rate under room temperature.

  Info
Periodical
Materials Science Forum (Volumes 510-511)
Edited by
Hyung Sun Kim, Yu Bao Li and Soo Wohn Lee
Pages
798-801
DOI
10.4028/www.scientific.net/MSF.510-511.798
Citation
H. S. So, H. C. Shin, B. S. Kim, Y. S. Yoo, "Controlled Release of Active Substance from Biodegradable Copolymer Matrix", Materials Science Forum, Vols. 510-511, pp. 798-801, 2006
Online since
March 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Jing Jing Zhang, Jun Liu, Hao Yu, Yu Zhang, Mei Fang Zhu, Yan Mo Chen
Abstract:Crosslinked UPM/PHBV/PVP fibers were successfully prepared using electrospinning process. The active pharmaceutical ingredient tetracycline...
1331
Authors: De Jie Zhou, Nian Feng Han, Xin De Tang
Abstract:The new poly(silyl ester) has been prepared by the polycondensation reaction of 1,5-dichloro-1,1,5,5-tetramethyl-3,3-diphenyl-trisi1oxane...
862
Authors: Juan Qin Xue, Jing Xian Li, Ming Wu, Wei Wang, Dong Ni Ma
Abstract:Using formaldehyde as a crosslinking reagena novel cross-linked chitosan resin was synthesized by orthogonal. The resin material with good...
279
Authors: Tang Wei Wang, Zhong Xiao Li, Hua Sheng Lu, Jia Ling Pu
Chapter 3: Green Information Record Material
Abstract:A reversible addition fragmentation chain transfer (RAFT) agent, 2-(dodecylthiocarbonothioylthio)propanoic acid (RAFT-1), was synthesized and...
331
Authors: Yue Zhao, Ming Tao Liang, Yoseop Kim, Xin Tan, Ling Zhang, Martina H. Stenzel
Chapter 2: Materials Science and Engineering
Abstract:A polymer drug delivery system was developed using crosslinked self-assembled micelles, which form stable coreshell particles. The block...
449