Paper Title:
Optimization of the Synthesis of Hydroxyapatite Powders for Biomedical Applications Using Taguchi's Method
  Abstract

A conventional method of chemical precipitation was used to produce hydroxyapatite (HAp) powders, with a molar ratio of Ca/P=1.67, for biomedical applications. The aim of this work was to study the effect of four control factors, namely pH, reaction temperature, reagent concentration and flow rate addition, at three levels, on the Ca/P ratio of the synthesized powders, using the Taguchi design of experiments method. Nine powders were synthesized using Ca(NO3)2ּ4H2O and (NH4)2HPO4 as starting reagents. The Ca/P molar ratio of each powder was determined by ICP-AES. Data obtained were used in the Taguchi’s design of experiments to optimize the Ca/P molar ratio. Results showed that the pH of the reaction is the main control parameter (74% contribution) affecting the Ca/P molar ratio of the powders. Therefore, attention should be paid to the control of the pH during the synthesis, in order to obtain HAp powders in a reproducible fashion. High pH values (9.5) and reaction temperature at 70 °C favoured the synthesis of HAp powders with a Ca/P ratio close to the target value of 1.67.

  Info
Periodical
Materials Science Forum (Volumes 514-516)
Edited by
Paula Maria Vilarinho
Pages
1025-1028
DOI
10.4028/www.scientific.net/MSF.514-516.1025
Citation
C. M.S. Ranito, C. A. Nogueira, J. Domingues, F. Pedrosa, F. A. C. Oliveira, J. P. Borges, "Optimization of the Synthesis of Hydroxyapatite Powders for Biomedical Applications Using Taguchi's Method", Materials Science Forum, Vols. 514-516, pp. 1025-1028, 2006
Online since
May 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: De An Yang, Zi Yang, Weijie Hu, Yuan Yuan Li, Huan Wang
Abstract:Gypsum powders and calcium phosphate/gypsum powders were synthesized by wet method. The influences of the pH and temperature on the...
1559
Authors: Nilce C.C. da Rocha, Elena Mavropoulos, Marcelo Henrique Prado da Silva, R. C. de Campos, Antonella M. Rossi
Abstract:Cadmium uptake by hydroxyapatite from aqueous solution was studied in time intervals between 2 minutes and 96 hours, using different Cd2+...
123
Authors: Koay Mei Hyie, Iskandar Idris Yaacob
Abstract:Fe/Pt bimetallic nanoparticles at various molar ratios have been prepared by simultaneous reduction of FeCl2 and H2PtCl6 with hydrazine...
45
Authors: Hong Bo Yu, Jing Wang, Hong Gao
Abstract:In present work mechanochemical synthesis of fine dispersed MgAl-CO3 LDHs is based on the preliminary mechanical activation of mixture of...
877
Authors: Kai Chen, Zhao Hui Huang, Ming Hao Fang, Yan Gai Liu, Xin Ouyang
Chapter 1: Novel Processing and Manufacturing
Abstract:Ti(C,N) powder was prepared via carbothermal reduction nitridation (CRN) using rutile and carbon black as the raw material. The phase...
32