How to effectively and efficiently integrate regional networked manufacturing systems is very important, and essential for speeding up agile collaboration between enterprises. The paper presents one kind of integrated framework of regional networked manufacturing systems, including software layer, business and application layer and coordination layer. Meanwhile, some key problems are analyzed. Furthermore, the paper studies a running mode of the systems integration. At last, the primary application situation of the framework in Chongqing of China is introduced, as well as some effects acquired.