This research proposes a new integrated framework to support the inter-enterprise function integration, system structure and collaboration over the networked environment. In contrast to the existing system integration, the proposed framework enables the systematic amalgamation of large complex product development PMIS (Project Management Information System) and correlative sub modules in ERP (Enterprise Resource Planning). In addition, this framework is more suitable for building the large-scale manufacturing systems that are prone to dynamic random changes of their environment. It is shown on a practical case -- the implementation of AA Company’s PMIS in the environment of ERP system. The result indicates that the information integration framework on the large complex product development PMIS with ERP is operable and practical.