The high-temperature deformation behavior of the single-phase α (Ti-7.0Al-1.5V) and α + β (Ti-6Al-4V) alloy were determined and compared within the framework of self-consistent scheme at various temperature ranges. For this purpose, isothermal hot compression tests were conducted at temperatures between 650°C ~ 950°C to determine the effect of α/β phase volume fraction on average flow stress under hot-working condition. The flow behavior of α phase was estimated from the compression test results of single-phase α alloy whose chemical composition is close to that of α phase of Ti-6Al-4V alloy. On the other hand, the flow stress of β phase in Ti-6Al-4V was predicted by using self-consistent method. The flow stress of α phase was higher than that of β phase above 750°C, while the β phase revealed higher flow stress than α phase at 650°C. Also, at temperature above 750°C, the predicted strain rate of β phase was higher than that of α phase. It was found that the relative strength between α and β phase significantly varied with temperature.