Paper Title:
Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo
  Abstract

The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency.

  Info
Periodical
Materials Science Forum (Volumes 539-543)
Main Theme
Edited by
T. Chandra, K. Tsuzaki, M. Militzer , C. Ravindran
Pages
641-646
DOI
10.4028/www.scientific.net/MSF.539-543.641
Citation
T. H. Kim, J. Hua, H. W. Kim, M. H. Cho, J. W. Nah, Y. J. Choi, C. S. Cho, "Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo", Materials Science Forum, Vols. 539-543, pp. 641-646, 2007
Online since
March 2007
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Price
$32.00
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