Paper Title:

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

Periodical Materials Science Forum (Volumes 539 - 543)
Main Theme THERMEC 2006
Edited by T. Chandra, K. Tsuzaki, M. Militzer , C. Ravindran
Pages 641-646
DOI 10.4028/www.scientific.net/MSF.539-543.641
Citation Tae Hee Kim et al., 2007, Materials Science Forum, 539-543, 641
Online since March, 2007
Authors Tae Hee Kim, Jin Hua, Hyun Woo Kim, Myung Haing Cho, Jae Woon Nah, Yun Jaie Choi, Chong Su Cho
Keywords Chemical Modification, Chitosan (CS), Receptor-Mediated Gene Delivery, Transfection Efficiency
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Abstract

The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency.