Paper Title:
pH-Sensitivity of N-Carboxyethyl Chitosan Hydrogel and Drug Controlled Release In Vitro
  Abstract

N-carboxyethyl chitosan (ACS) was formed by a Micheal reaction. Through the analysis of IR and 1H-NMR spectra, the Micheal reaction was carried out between - NH2 of chitosan and - C = C - of acrylic acid. ACS hydrogel (ACSG) was prepared by cross-linking with glutaraldehyde. ACSG show pH-sensitive swelling behavior, and the smallest swelling rate (SR) of ACSG is in pH5.0 buffer solution.With dosage of glutaraldehyde increasing, the SR of ACSG decreased. With grafting degree (GD) increasing, the SR of ACSG increased first and decreased afterward. Using bovine serum albumin (BSA) as a model medicine, the releasing behaviors of ACSG were investigated in vitro. In simulated gastric and intestinal fluid, the ACSG loading BSA (GD=20.45%) has better releasing behaviors.

  Info
Periodical
Materials Science Forum (Volumes 561-565)
Main Theme
Edited by
Young Won Chang, Nack J. Kim and Chong Soo Lee
Pages
1455-1458
DOI
10.4028/www.scientific.net/MSF.561-565.1455
Citation
Z. W. Li, L. Y. Zhang, Q. X. Zeng, "pH-Sensitivity of N-Carboxyethyl Chitosan Hydrogel and Drug Controlled Release In Vitro", Materials Science Forum, Vols. 561-565, pp. 1455-1458, 2007
Online since
October 2007
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$32.00
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