The tensile and plain fatigue properties of the β-type titanium alloy, Ti-29Nb-13Ta-4.6Zr alloy (TNTZ), which was subjected to various thermomechanical treatments, and cast TNTZ were investigated in order to judge its potential for biomedical and dental applications. The tensile strengths of TNTZ aged after solution treatment and that aged after cold rolling decrease with an increase in the aging temperature; however, their elongation exhibits an opposite trend. TNTZ composed of the ω phase or the ω and α phases in the β phase exhibits a tensile strength of about 1000 MPa or more. The tensile properties of the cast TNTZ with and without a surface reaction layer is are not significantly different, and are almost identcal to those of as-solutionized TNTZ. The plain fatigue strengths of TNTZ aged after solution treatment and those of TNTZ aged after cold rolling increase with the aging temperature. In particular, TNTZ aged at 723 K after cold rolling exhibits the highest fatigue strength in both the low- and high-cycle fatigue life regions. Further, the plain fatigue limit, which is about 770 MPa, is nearly equal to that of hot-rolled Ti-6Al-4V ELI alloy subjected to aging after solution treatment; Ti-6Al-4V ELI alloy is a representative α+β-type titanium alloy for biomedical applications. The plain fatigue strength of cast TNTZ with a surface reaction layer is considerably less than that of the as-cold-rolled and as-solutionized TNTZ. Consequently, in the low-fatigue life region, the fatigue crack easily occurs at the surface reaction layer, which is brittle, and in the high-fatigue life region, the fatigue crack occurs at the sites of casting defects (shrinkage). The fatigue limits range from 180 MPa to 200 MPa.