In this paper, numerical simulation software of AnyCasting was adopted for simulate processes of titanium aluminum alloys filling and solidifying. Pour temperature, pressure head and rotate speed had an important effect on casting quality. The former parameters as factors orthogonal experiment L7 (33) was carried out and the experimental scheme was optimized. The results showed that as the pour temperature rising the filling time had no change, solidifying time had a large increase and casting defect tendency tended to little. Filling time and solidifying time decreased with the pressure head rising and casting defect tendency changed from little to large. The effect of rotating speed on filling time was as that of pressure head, solidifying time had little change and casting defects tendency of casting changed from little to great. With the optimized parameters of casting temperature of 1650°C, pressure head of 0.2m and rotating speed of 200r/min the investment cast filling and solidifying simulations was made out. The results showed that in the optimized simulation the liquid metal filled mold from the top down, filling course was smooth and complete and temperature field was even. Through analyses of casting defects the optimized scheme proved to be logical.