High speed wire-rod rolling is a typical large deformation process which includes geometry, material and boundary condition non-linearity, thus it belongs to a highly nonlinear problem. The finite element models of the billet and the rollers in the intermediate rolling region had been established based on actual sizes by using 3-D thermo-mechanical coupling FEM and advanced contact analysis technology. The deformation field, stress, strain, temperature field and rolling force of the billet were calculated and analyzed in the rolling passes precisely. The distribution and change characteristics of temperature had been discussed especially. The results of the simulation are reliable and precise, which are useful for practical manufacture and the optimization of process-parameters.