High power lasers, including CO2 laser, Nd:YAG laser, Excimer laser, Diode laser, LD pumped YAG laser, LD pumped Disk laser, LD pumped Fiber laser and Femto second laser, are now used as a modern tool for industries as well as a computer alike in the 4th wave of modernization. Lasers are currently used for welding, cutting, drilling, cladding, direct fabrication, marking, cleaning, micro-machining peening and forming of materials in modernized factories. The joining speed (= product of welding speed and penetration depth) of 45,000mm2/min for steel sheet can be obtained by a 10kW Yb: fiber laser and is that of 50kW electron beam welding, which require the vacuum chamber. As a result of large numbers of research and developments the Advanced Laser Integrated Manufacturing System (ALIMS) using high power diode lasers has been developed and used for modernization in many industrialized countries. The laser materials processing is now penetrated as a machining tool into many industries. In the present paper, an advanced laser integrated manufacturing systems and its applications to industries such as automotive, electronics, ship building and steel making industry are introduced. In addition, development of an advanced laser integrated manufacturing system using a 2kW fiber laser for welding a car panel and “Laser Roll Welding” system for dissimilar metal joints such as mild steel/high strength steel to aluminium alloys, titanium to aluminium and steel to titanium, is described for modernization of industries. It will be a magnificent for the industries. And the 4th wave of modernization and opto-mechatronics will be promoted more by laser/photon technology in the future.