Differential Scanning Calorimetry (DSC) is a thermal analysis technique that measures the energy absorbed or released by a sample as a function of temperature or time. DSC has wide application for analysis of solid state reactions and solid-liquid reactions in many different materials. In recent years, DSC has been applied to analyze materials and alloys processed through Severe Plastic Deformation (SPD). The basic principle of SPD processing is that a very high strain is introduced into materials which achieve significant grain refinement and improve properties of materials. This review paper presents some recent examples of the applications of DSC for materials subjected to SPD, especially by Equal-Channel Angular Pressing and High-Pressure Torsion.