Paper Title:
Mineralization of Chitosan Membrane Using a Double Diffusion System for Bone Related Applications
  Abstract

Chitosan membranes were subjected to a pre-treatment in a double diffusion system, with a calcium solution in one chamber and a phosphate solution in the other chamber. Both chambers were separated by the chitosan membrane and subject to three mineralization periods (5, 10 and 15 minutes). After this pre-treatment the bioactivity of the different calcium phosphate coatings formed was tested for different periods of immersion time, 7, 14 and 21 days at room temperature and 37°C, in acellular simulated body fluid (1.0x). The results obtained demonstrated that the calcium phosphate coatings formed during the pre-treatment process are bioactive. It was found that the calcification is effective just in the side of the membrane exposed to the calcium solution chamber. This enabled to develop membranes with asymmetric osteoinductive properties that can be useful in different orthopedic applications.

  Info
Periodical
Materials Science Forum (Volumes 587-588)
Edited by
António Torres Marques, António Fernando Silva, António Paulo Monteiro Baptista, Carlos Sá, Fernando Jorge Lino Alves, Luís Filipe Malheiros and Manuel Vieira
Pages
77-81
DOI
10.4028/www.scientific.net/MSF.587-588.77
Citation
S. Gomes, M. E. Boulon, A.L. Oliveira, I. B. Leonor, J. F. Mano, R. L. Reis, "Mineralization of Chitosan Membrane Using a Double Diffusion System for Bone Related Applications", Materials Science Forum, Vols. 587-588, pp. 77-81, 2008
Online since
June 2008
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Price
$32.00
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