This paper presents some of the results of an investigation on the possible applications of use of waste concrete aggregates from mixer trucks concrete productions (WCA) in concrete. The investigation has been carried out using factorial design for experimental design. For the study, the physical and mechanical properties along their durability of concrete produced with WCA were investigated and the results presented. Concrete mixtures were prepared using WCA as the replacement of natural fine aggregate at the level 10%, 20% and 30 wt.% with water/cement ratios of 0.40, 0.50 and 0.60. Properties of fresh and hardened concrete were evaluated: fresh unit weight, consistency, 7-day and 28-day compressive strength were carried out in specimens. The necessary data for establishing a mix proportion design and a quality control method are obtained using a full factorial design 32. The influence of level of WCA on the mineralogical composition has been established, and its suitability for use in a concrete application has been assessed. Empirical contour plots for the physical-mechanical properties of fresh and hardened concrete with WCA were obtained via regression analysis, which predict that as the amount of waste increases, has no or little effect on the compressive strength of concrete mixes. The results form confirmation experiments justify the prediction from the statistical approach.