Paper Title:
The Effects of Different Hydroxyapatite/TiO2 Composite Coatings on Protein Expression of Osteoblast
  Abstract

Hydroxyapatite/TiO2 composite material was coated onto Ti25Nb3Mo2Sn3Zr (TLM) alloy substrate. To study the effects of hydroxyapatite/TiO2 composite coatings on bone-related protein expression, the osteoblast were cultured with composite coatings for different times. The phase transformation and compound formation of the HA/TiO2 coatings were investigated using XRD (X-ray diffraction). The mRNA expression of Type I collagen, alkaline phosphatase (ALP) and osteocalcin were studied by RT-PCR (reverse transcriptional polymerase chain reaction). The titania delayed the crystallization of HA. The mRNA expressions of Type I collagen are decreased as the increasing of TiO2 percentage. The mRNA expressions of osteocalcin are approached. The ALP expression on H4 coating (HA/TiO2 mol ration is 5) after the osteoblast cultured with composite coating for 6 days is the highest. The increasing of TiO2 amount decreases the bioactivity of the composite coatings.

  Info
Periodical
Materials Science Forum (Volumes 610-613)
Main Theme
Edited by
Zhongwei Gu, Yafang Han, Fusheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
Pages
1104-1108
DOI
10.4028/www.scientific.net/MSF.610-613.1104
Citation
J. Y. Han, Z. T. Yu, L. Zhou, "The Effects of Different Hydroxyapatite/TiO2 Composite Coatings on Protein Expression of Osteoblast", Materials Science Forum, Vols. 610-613, pp. 1104-1108, 2009
Online since
January 2009
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