Paper Title:
Study on Preparation and Properties of Nitric Oxide Releasing Polyurethane
  Abstract

In this study, a novel nitric oxide (NO) endogenously releasing polyurethane (PU) material, i.e. PU-g-L-cysteine(PU-Cys), was synthesized by grafting L-cysteine on the film surface. Fluorescence analysis and a BCA method were used to characterize qualitatively and quantitatively the grafted L-cysteine. The results showed that L-cysteine was successfully immobilized on the PU film surface and the density of L-cysteine grafted was calculated to be 15.3nmol/cm2. The NO releasing behavior study of PU-Cys film demonstrated that endogenous NO could be continuously released from PU-Cys film and the accumulated releasing amount within 3h added up to 1.06nmol/cm2. The releasing rate of NO was well matchable to the self-releasing rate of resting platelets in human body. The results of dynamic blood clotting test and hemolysis ratio measurement showed that PU-Cys film had a better haemocompatibility than PU film, which might be the result of endogenously released NO inhibiting platelet adhesion and thrombus formation. Therefore, PU-Cys with the property of endogenous NO releasing is expected to be an ideal blood compatibility material in clinical application.

  Info
Periodical
Materials Science Forum (Volumes 610-613)
Main Theme
Edited by
Zhongwei Gu, Yafang Han, Fusheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
Pages
1237-1243
DOI
10.4028/www.scientific.net/MSF.610-613.1237
Citation
J. H. Zhao, M. Tu, R. Zeng, J. Geng, Z. G. Cha, C. R. Zhou, "Study on Preparation and Properties of Nitric Oxide Releasing Polyurethane", Materials Science Forum, Vols. 610-613, pp. 1237-1243, 2009
Online since
January 2009
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Yan Jun Liu, Chun Ying Lv, Jia Yang
Abstract:To improve the antifouling property of PP membrane, a series of amphoteric charged membranes was prepared by the introduction of cysteine on...
2024
Authors: Se Shi, Ji Mei Zhang, Zhao Dai
Chapter 1: Materials Engineering
Abstract:High-Fluorescence Mn-doped ZnS quantum dots ( QDs) capped with L-Cysteine (L-Cys) were prepared in the aqueous were presented in this paper....
3
Authors: Xin Hui Zhang, Yan Yan Wei, Chi Zhang, Miao Miao Chi, Jian Zhang, Ai Hui Liang
Chapter 2: Material Science and Materials Processing
Abstract:Using PEG-10000 and sodium citrate as stabilizer, and NaBH4 as reducer, a stable nanosilver (AgNPs) sol was prepared. In pH 6.6...
741
Authors: Hidefumi Miyata, Kazuhiro Yumoto, Kanako Itoh, Miki Sasahara, Hiroki Kawaura, Nobuyuki Oshima, Taiho Shuzuki, Shunsuke Takahashi, Masahiko Oshige, Shinji Katsura
VII. Medical Science and Engineering
Abstract:A method for preparing a high-density His-tagged protein array was developed. The method is based on specific binding between His-tags and Ni...
219
Authors: Hae Jo Kim
Abstract:Two novel fluorescent chemodosimeters will be presented for the selective detection of cysteine over homocysteine and glutathione in aqueous...
19