Paper Title:
Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release
  Abstract

Crosslinked UPM/PHBV/PVP fibers were successfully prepared using electrospinning process. The active pharmaceutical ingredient tetracycline hydrochloride (TH) was loaded onto the electrospun fibers through after-treatment method. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and in vitro dissolution tests were carried out to characterize the medicated electrospun fibers. The SEM and FTIR results clearly showed the difference between the UPM / PHBV and UPM/ PHBV/ PVPelectrospun fibers. The pharmaceutical tests results indicated that the fibers had good drug-loaded capability and sustained-release properties. The as-prepared fibers might find possible applications as wound dressings or transdermal drug delivery systems.

  Info
Periodical
Materials Science Forum (Volumes 610-613)
Main Theme
Edited by
Zhongwei Gu, Yafang Han, Fusheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
Pages
1331-1334
DOI
10.4028/www.scientific.net/MSF.610-613.1331
Citation
J. J. Zhang, J. Liu, H. Yu, Y. Zhang, M. F. Zhu, Y. M. Chen, "Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release ", Materials Science Forum, Vols. 610-613, pp. 1331-1334, 2009
Online since
January 2009
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Price
$32.00
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