Paper Title:
Characterization of an Insoluble Collagen Sponge and the Potential for Tissue Engineering Scaffold
  Abstract

Collagen has been widely used in biomedical field, such as scaffolds for tissue engineering. However, the rapidly biodegradation and weak mechanical strength of collagen limited its application. In this study, an insoluble collagen extracted from cattle hide was designed as scaffold to act as a three-dimensional substrate for tissue engineering. The received insoluble collagen sponge was analyzed by scanning electron microscopy, infrared spectroscopy, mechanical testing and thermogravimetric-differential thermal analysis. In addition, the degradation was performed in vitro using collagenase. The results showed that the insoluble collagen had the same triple helical domain as acid-soluble collagen, while the compression strength was greatly improved and the degradation rate was reduced. The insoluble collagen sponge with good stability should be promising in tissue engineering scaffold applications.

  Info
Periodical
Materials Science Forum (Volumes 610-613)
Main Theme
Edited by
Zhongwei Gu, Yafang Han, Fusheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
Pages
1378-1381
DOI
10.4028/www.scientific.net/MSF.610-613.1378
Citation
L. Zhang, Y. Zhang, B. Jiang, H. S. Fan, X. D. Zhang, "Characterization of an Insoluble Collagen Sponge and the Potential for Tissue Engineering Scaffold", Materials Science Forum, Vols. 610-613, pp. 1378-1381, 2009
Online since
January 2009
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Price
$32.00
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