By means of the measurement of creep curves and microstructure observation, the influence of T6 heat treatment on the microstructure and creep properties of the wrought Ti-6Al-4V the alloy has been investigated. The experimental results showed that the microstructure of the wrought alloy consists of the strip-like + phases, which results in the alloy displaying a higher strain rate and shorter creep life under the test condition of 575 MPa and 400°C. After T6 treatment, the creep life of the alloy at same conditions enhanced to 548 h from 66 h. Microstructure of T6 treated alloy consisted of the primary and /phases, and signification amount of the bundle-likephase precipitated along the different orientations in the grains, this is a main reason of enhancing creep life of the alloy. During forging, the denser dislocation rows were activated in the local region of the matrix in the alloy. During creep, the deformed mechanism of the alloy was the double orientations slip of and dislocations activated on the pyramidal planes in phase.