Compared with the actual operation, computational simulation will save the cost and provide more valuable references or guiding significance for the real production. Using professional forming software DEFORM-3D, the upsetting process of WE43 magnesium alloy was simulated. Based on the actual flow stress data, the simulation model of WE43 magnesium alloy was created in DEFORM-3D. Results show that the uniform distribution of the temperature of WE43 magnesium alloy during the forming process is beneficial to the structural homogeneity and contributes to excellent flowing property. There is the stress concentration in the edge and slide face of the billet. So during the process of compression, the fracture will appear earlier in the edge and slide face of the sample.