Due to the rapid development in recent cutting technology, demands for different types of precise cutting tools become increasingly complicated. Since the design and grinding of end-mills are the last and the most important processing for cutting tools. The geometrical accuracy and the cutting performance of an end-mill depend essentially on the grinding. However, the complicated geometry of an end-mill will be ground by the specific software of CAD/CAM on the 5-axis CNC tool grinding machine. The precision of end-mill grinder will be determined by the performance of 5-axis CNC tool grinder and setting of grinding parameters. Three regulation factors for grinding are grit size of the diamond grinding wheel, grinding speed and the feeding speed. The variable ranges of each parameter can be divided in large, medium and small interval. In this study for an end-mill with fixed geometrical profile, a series of different grinding parameters have been utilized by the 33 factorial experiment planning. And tool grinding experiments for the rod material specification of tungsten carbide have been performed by 5-axis CNC tool grinder. After grinding, surface roughness of tools will be measured. The reliability and precision of the end-mill grinding can be enhanced by the prediction model of polynomial network for surface roughness of end-mills. Besides, the database system for cutting tool has benn established. Totally 4802 data were constructed in the relational database according to the characteristics of tools.