This paper presents the research on calibration for a 6-component huge force sensor. 6-component huge force sensor is used to measure the loading forces Fx, Fy, Fz and moments Mx, My, Mz. Static calibration equipment is studied. In order to express the relationship between input force signal and output electric signal when the sensor is used, a coupling matrix is needed. In this paper, a method for establishing the coupling matrix is developed. The matrix is used to calculate the input signal when sensor works in the simulation application, and the result shows it serves the sensor well.