Advanced engineering techniques have been used in medical area wildly, but experience of surgeon is still relied heavily in dental implant in China. Aiming at this problem, a methodology of minimally invasive dental implant based on techniques of digital design and manufacturing is proposed, the procedure and some key problems of design and manufacturing are studied deeply. With designed implant plan based on 3D computer model reconstructed from CT images of oral and point cloud of oral plaster model, a surgical guide on the mucosa and teeth surface can be designed and fabricated. In clinical operation, the surgical guide is fixed on oral inner surface directly to guarantee the implant plan implemented accurately. Contrast to traditional dental implant, the minimally invasive surgery can be realized without soft tissue flap, and the temporary denture can be fabricated and fixed in the oral to recover the tooth function immediately. Clinical applications illustrate that, with proposed methodology, the efficiency and quality of implant operation can be improved effectively.