The design and machining quality of mold core of luminaire reflector is the key to luminaire manufacturing. According to the structural characteristics of the mold core with axisymmetric uniform-distribution reflecting cells, the mathematical model with five-axis NC programming of this mold core was established. Based on five-axis CNC machine tools with dual rotary tables, then, the NC automatic programming calculation for this mold core was researched. Besides, a simple three-dimensional entity simulation was discussed. In this way, the three-dimensional entity simulation of automatic programming and processing in 5-axis NC machining of this mold core was realized.