Paper Title:
Biocompatibility Aspects of NiTi-Based Medical Implants
  Abstract

Nickel-titanium is a functional alloy currently used in various clinical applications, especially in vascular stents. There is an increased interest in the orthopaedic use of NiTi-based implants. The alloy enables the manufacture of applications of constant load, controllable motion, and minimal invasiveness. NiTi is considered biocompatible and it possesses mechanical properties that make it an especially good candidate for bone tissue surroundings. In our studies, we have investigated the effects of surface properties of NiTi on its biocompatibility. The martensitic phase was shown to have lower biocompatibility of material in comparison with austenitic NiTi. Cellular cytotoxicity increased and cell adhesion diminished on martensite phase. This was observed with both osteoblasts and osteoclasts. Our studies showed that the thickness of the oxide layer does not necessarily enhance the biocompatibility. The surface state of NiTi is strongly affected by thermal oxidation. Surface properties affect the initial adsorption of proteins and other macromolecules onto the biomaterial surface; this in turn impacts the following cellular responses, such as proliferation and differentiation, which are dictated by adhesion to the extracellular matrix components. Since adhesive force is connected to the interaction with the adsorbed molecules, it might be an important factor in the biocompatibility. Sol-gel derived titania-silica surface treatment was observed to increase the bone-implant coating of functional intramedullary NiTi nails. Sol-gel treatment together with the bending force increased the fixation of the implant (osseointegration). These studies indicate that the surface properties of NiTi are important for its biocompatibility.

  Info
Periodical
Materials Science Forum (Volumes 631-632)
Edited by
Akira Kawasaki, Akinaga Kumakawa and Masayuki Niino
Pages
175-179
DOI
10.4028/www.scientific.net/MSF.631-632.175
Citation
T. Jämsä, V. Muhonen, A. Danilov, J. Tuukkanen, "Biocompatibility Aspects of NiTi-Based Medical Implants", Materials Science Forum, Vols. 631-632, pp. 175-179, 2010
Online since
October 2009
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: E. Czarnowska, A. Zajaczkowska, A. Sowinska, M.M. Godlewski, Jaroslaw Mizera, T. Wierzchon
Abstract:A diffusion surface layer of Ti3P+Ti-Ni type was produced on Ti6Al4V titanium alloy by a chemical electroless nickel-phosphorous deposition...
240
Authors: N. R. Ha, Z. X. Yang, Kyu Hong Hwang, J. K. Lee
Abstract:Pure Titanium alloys are superiorities of biocompatibility, mechanical properties and chemical stability. The biocompatibility of Ti alloy...
177
Authors: Kun Mediaswanti, Cui'e Wen, Elena P. Ivanova, Christopher C. Berndt, Francois Malherbe, James Wang
Chapter 9: New Functional Materials
Abstract:Titanium and titanium alloys scaffolds have been widely explored in many load-bearing orthopaedic applications due to their excellent...
1634
Authors: Cui'e Wen, Yun Cang Li
Chapter 5: Biomedical Titanium Alloys
Abstract:Titanium and some of its alloys have received considerable attention for biomedical applications in recent years due to their excellent...
201
Authors: Yun Cang Li, Chao Han, Xin Kun Zhu, Cui'e Wen, Peter D. Hodgson
Chapter 5: Biomedical Titanium Alloys
Abstract:The mechanical property of porous pure titanium (Ti) scaffold with high porosity might become poorer than that of natural bone. In this...
242