Tri-Block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-Delivery Systems |
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| Journal | Materials Science Forum (Volumes 636 - 637) |
|---|---|
| Volume | Advanced Materials Forum V |
| Edited by | Luís Guerra ROSA and Fernanda MARGARIDO |
| Pages | 76-81 |
| DOI | 10.4028/www.scientific.net/MSF.636-637.76 |
| Citation | M.L.D.S. Tebaldi et al., 2010, Materials Science Forum, 636-637, 76 |
| Online since | January, 2010 |
| Authors | M.L.D.S. Tebaldi, T.C. Chaparro, A.M. Santos |
| Keywords | Poly(Acrylic Acid), Poly(t-butyl acrylate), Poly(vinylcaprolactam), RAFT Polymerization, Tri-Block Copolymer |
| Abstract | Tri-block copolymer with pH- and thermo-responsive consisting of poly(t-butylacrylate) and poly(vinylcaprolactam), (PtBA/PVCL) were prepared by RAFT polymerization and characterized by gel permeation chromatography (GPC) and 1H NMR. PtBA and PVCL were used as macro chain-transfer agents (MCTA) to synthesize PtBA-b-PVCL-b-PtBA and/or PVCL-b-PtBA-b-PVCL, which after partial hydrolysis led to amphiphilic tri-block copolymers P(tBA-co-AA)-b-PVCL-b-P(tBA-co-AA) and/or PVCL-b-P(tBA-co-AA)-b-PVCL. |
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