New Ti-based and Zr-based metallic wires for the future application as biomaterials were developed by arc-melting type melt-extraction method. Zr-based metallic glass wire, -Ti type Ti-Zr binary wire and -Ti type Ti-Nb-Ta-Zr (TNTZ) wire show high tensile strength and good vending ductility. Zr-based metallic glass wire shows extremely high tensile strength over 1GPa and large elastic strain limit reached approximately 2%. Ti-Zr binary alloy shows high wire-shape forming tendency during melt-extraction, and high Ti concentration Ti90Zr10 alloy wire was obtained. TNTZ wire shows superior bending ductility and full ductility is achieved.