Paper Title:
Protein Adsorption on Topographically Structured Surfaces: A Mesoscopic Computer Simulation for the Prediction of Prefered Adsorption Sites
  Abstract

In this study the influence of edges and spikes of a topographical nanostructure on the adsorption behavior of proteins at a solid-liquid interface is examined by a computer simulation. An algorithm has been developed, which combines a Finite Differences field calculation with Brownian Dynamics. A (16 nm)3 nano-cube with sharp edges as well as flat faces was chosen as model system and the adsorption of Hen Egg White Lysozyme was investigated. An increased adsorption rate along the edges of a the model cube is reached in the initial adsorption phase under consideration of electrostatic and dispersion interactions. At later times also the surfaces of the cube are covered, if the salt concentration is sufficient to screen the repelling protein-protein electrostatic interaction.

  Info
Periodical
Materials Science Forum (Volumes 638-642)
Main Theme
Edited by
T. Chandra, N. Wanderka, W. Reimers , M. Ionescu
Pages
542-547
DOI
10.4028/www.scientific.net/MSF.638-642.542
Citation
P. Elter, R. Lange, R. Thull, U. Beck, "Protein Adsorption on Topographically Structured Surfaces: A Mesoscopic Computer Simulation for the Prediction of Prefered Adsorption Sites ", Materials Science Forum, Vols. 638-642, pp. 542-547, 2010
Online since
January 2010
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