Paper Title:
Selenium Nanocluster Coatings: Transforming Current Orthopedic Materials into Inhibiting Bone Cancer
  Abstract

Selenium (Se) nanoclusters were coated on three different orthopedic materials: Titanium, stainless steel and ultra high molecular weight polyethylene (UHMWPE). There different coating densities were achieved on each type of substrate. The uncoated and coated Ti and SS substrates were then used in experiments with either normal healthy osteoblasts (bone-forming cells) or cancerous osteoblasts (osteosarcoma) or a combination of both. For the first time, it was shown that the substrates coated with Se nanoclusters promoted (or at least maintained) normal osteoblast proliferation and inhibited cancerous osteoblast growth in both separate culture experiments and co-culture experiments. Thus, this study introduced to the orthopedic cancer community for the first time a coating material (Se) which may inhibit bone cancer growth and promote normal bone growth.

  Info
Periodical
Materials Science Forum (Volumes 638-642)
Main Theme
Edited by
T. Chandra, N. Wanderka, W. Reimers , M. Ionescu
Pages
718-723
DOI
10.4028/www.scientific.net/MSF.638-642.718
Citation
P. A. Tran, L. Sarin, R. H. Hurt, T. J. Webster, "Selenium Nanocluster Coatings: Transforming Current Orthopedic Materials into Inhibiting Bone Cancer", Materials Science Forum, Vols. 638-642, pp. 718-723, 2010
Online since
January 2010
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