Spray deposition is a novel process which is used to manufacture rapidly solidified bulk and near-net-shape preforms. In this paper, Al-8.6Zn-2.6Mg-2.2Cu alloy was synthesized by the spray atomization and deposition technique. The microstructural development during subsequent hot extrusion, hot rolling and canned forging was investigated by means of scanning electron microscope and X-ray diffraction. The results indicate that the spray-deposited alloy exhibits a uniform microstructure composed of the Al matrix and Mg(ZnCu)2 compounds with various shape. The fragmentation of the Mg(ZnCu)2 phases in the alloy has been regarded as one of the main phenomena during extrusion, rolling and forging. Under T6 temper condition, the hot-extruded Al-Zn-Mg-Cu alloy displays superior strength, and higher than hot-rolled and canned-forged ones.