Paper Title:
Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films
  Abstract

Hydrophilic ciprofloxacin hydrochloride and hydrophobic sirolimus were used as model drugs, and poly(dl-lactic-co-glycolic acid) 50/50 (PLGA 50/50) was used as the drug carrier to investigate the effects of hydrophilicity/hydrophobicity of a drug on its release properties from PLGA films. The results showed that ciprofloxacin hydrochloride induced faster release curves than sirolimus, and it also promoted the weight loss of films, while sirolimus inhibited the weight loss of films. However, both drugs inhibited the degradation of biodegradable carrier.

  Info
Periodical
Materials Science Forum (Volumes 675-677)
Edited by
Yi Tan and Dongying Ju
Pages
369-372
DOI
10.4028/www.scientific.net/MSF.675-677.369
Citation
H. Z. Liu, M. Qi, B. Guo, H. H. Liu, "Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films", Materials Science Forum, Vols. 675-677, pp. 369-372, 2011
Online since
February 2011
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Price
$32.00
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