Laser cladding of Ni-based alloy on Mg-alloy was achieved by using brass as transition layer on substrate. The Ni-based alloy layer free of cracks and porosities was bonded metallurgically with the Mg substrate using brass as the transitional layer. The Ni-based cladding layer was mainly composed of Cr2Ni3, FeNi3, AlNi3 while the content of Mg, Al, Cu and Zn is very low in the cladding layer. Microhardness and the wear resistance of the sample were tested, whose results indicated that microhardness and wear resistance increased 12.8 times and 13.3 times, respectively compared with the substrate. In addition, the corrosion potential (Ecorr) of the sample was much higher than that of untreated materials.